D68.51

Activated protein C resistance

Billable / specific

D68.51 is a billable, specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes in FY2027.

Inclusion terms

Applicable to

  • Factor V Leiden mutation

Excludes1

Not coded here — never report together with this code.

  • antiphospholipid syndrome (D68.61) (from D68.5)
  • lupus anticoagulant (D68.62) (from D68.5)
  • secondary activated protein C resistance (D68.69) (from D68.5)
  • secondary antiphospholipid antibody syndrome (D68.69) (from D68.5)
  • secondary lupus anticoagulant with hypercoagulable state (D68.69) (from D68.5)
  • secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69) (from D68.5)
  • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0) (from D68.5)
  • systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312) (from D68.5)
  • thrombotic thrombocytopenic purpura (M31.19) (from D68.5)
  • abnormal coagulation profile NOS (R79.1) (from D68)

Excludes2

Not included here — may be reported together when both conditions exist.

  • autoimmune disease (systemic) NOS (M35.9) (from D68)
  • certain conditions originating in the perinatal period (P00-P96) (from D68)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A) (from D68)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) (from D68)
  • endocrine, nutritional and metabolic diseases (E00-E88) (from D68)
  • human immunodeficiency virus [HIV] disease (B20) (from D68)
  • injury, poisoning and certain other consequences of external causes (S00-T88) (from D68)
  • neoplasms (C00-D49) (from D68)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94) (from D68)
  • coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1) (from D68)
  • coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3) (from D68)

Also known as

  • Factor V Leiden mutation
  • Hypercoagulable, activated protein C resistance
  • Hypercoagulable, factor V Leiden mutation
  • Mutation, factor V Leiden
  • Resistance, resistant, activated protein C

Parent code

  • D68.5Primary thrombophiliaHeader

Related codes

  • D68.52Prothrombin gene mutationBillable
  • D68.59Other primary thrombophiliaBillable

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