Activated protein C resistance
Billable / specific
D68.51 is a billable, specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes in FY2027.
Inclusion terms
Applicable to
- Factor V Leiden mutation
Excludes1
Not coded here — never report together with this code.
- antiphospholipid syndrome (D68.61) (from D68.5)
- lupus anticoagulant (D68.62) (from D68.5)
- secondary activated protein C resistance (D68.69) (from D68.5)
- secondary antiphospholipid antibody syndrome (D68.69) (from D68.5)
- secondary lupus anticoagulant with hypercoagulable state (D68.69) (from D68.5)
- secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69) (from D68.5)
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0) (from D68.5)
- systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312) (from D68.5)
- thrombotic thrombocytopenic purpura (M31.19) (from D68.5)
- abnormal coagulation profile NOS (R79.1) (from D68)
Excludes2
Not included here — may be reported together when both conditions exist.
- autoimmune disease (systemic) NOS (M35.9) (from D68)
- certain conditions originating in the perinatal period (P00-P96) (from D68)
- complications of pregnancy, childbirth and the puerperium (O00-O9A) (from D68)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99) (from D68)
- endocrine, nutritional and metabolic diseases (E00-E88) (from D68)
- human immunodeficiency virus [HIV] disease (B20) (from D68)
- injury, poisoning and certain other consequences of external causes (S00-T88) (from D68)
- neoplasms (C00-D49) (from D68)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94) (from D68)
- coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1) (from D68)
- coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3) (from D68)
Also known as
- Factor V Leiden mutation
- Hypercoagulable, activated protein C resistance
- Hypercoagulable, factor V Leiden mutation
- Mutation, factor V Leiden
- Resistance, resistant, activated protein C
Parent code
- D68.5Primary thrombophiliaHeader