G90.81

Serotonin syndrome

Billable / specific

G90.81 is a billable, specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes in FY2027.

Inclusion terms

Applicable to

  • Serotonin toxicity

Excludes1

Not coded here — never report together with this code.

  • dysfunction of the autonomic nervous system due to alcohol (G31.2) (from G90)

Excludes2

Not included here — may be reported together when both conditions exist.

  • certain conditions originating in the perinatal period (P04-P96) (from G90)
  • certain infectious and parasitic diseases (A00-B99) (from G90)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A) (from G90)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99) (from G90)
  • endocrine, nutritional and metabolic diseases (E00-E88) (from G90)
  • injury, poisoning and certain other consequences of external causes (S00-T88) (from G90)
  • neoplasms (C00-D49) (from G90)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94) (from G90)

Code first

Sequence the underlying condition first.

  • poisoning due to drug or toxin, such as:
  • linezolid (T36.8X- with sixth character 1-4)
  • monoamine oxidase inhibitors (T43.1X with sixth character 1-4)
  • selective serotonin and norepinephrine reuptake inhibitors [SSNRI] (T43.21 with sixth character 1-4)
  • selective serotonin reuptake inhibitors [SSRI] (T43.22 with sixth character 1-4)

Use additional code

Add a code to identify the following, if applicable.

  • code for adverse effect, if applicable, to identify drug, such as:
  • linezolid (T36.8X5)
  • monoamine oxidase inhibitors (T43.1X5)
  • selective serotonin and norepinephrine reuptake inhibitors [SSNRI] (T43.215)
  • selective serotonin reuptake inhibitors [SSRI] (T43.225)
  • code, if applicable, to identify:
  • disseminated intravascular coagulation (D65)
  • hypertensive crisis (I16.-)
  • metabolic acidosis (E87.2-)
  • shock, not elsewhere classified (R57.-)
  • toxic encephalopathy (G92.-)
  • ventricular tachycardia (I47.2-)

Also known as

  • Serotonin toxicity
  • Syndrome, serotonin

Parent code

  • G90.8Other disorders of autonomic nervous systemHeader

Related codes

  • G90.89Other disorders of autonomic nervous systemBillable

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