Z16.35

Resistance to multiple antimicrobial drugs

Billable / specific

Z16.35 is a billable, specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes in FY2027.

Inclusion terms

Note: Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
Note: (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
Note: (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
Note: The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Not coded here — never report together with this code.

Resistance to multiple antibiotics only (Z16.24)
resistance to antibiotics (Z16.1-, Z16.2-) (from Z16.3)
Methicillin resistant Staphylococcus aureus infection (A49.02) (from Z16)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212) (from Z16)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02) (from Z16)

Sequence the underlying condition first.